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Medicine Preparation
Cowles Dissolver - High speed dispersion of powders in
liquids providing for homogenous mixtures. While mixing all
agglomerates are broken down, the solids are reduced to their
primary particle size and completely wetted.
Urschell Mill - Used for wet milling of products with large
particle size. Raw materials which are larger than 80 mesh must be
reduced in size before they can be encapsulated. The Urshell is a
one pass mill requiring less time for milling than standard mills.
Fryma Dearator- During milling and dispersion air is
created into to the fill mass. The oxygen which is created by
processing will cause oxidation and make fats and oils to go
rancid, creates discoloration and improper fill weights on the
encapsulation machines. After running the fill mass through the
dearator the products not only look smoother and glossier, they
have greater stability and no sign of foam.
1500 Liter Tanks- The
large tanks with anchor style stirrers are used for blending of
oils in order to provide a homogenous mixture.
Gelatin
Preparation
1150 Litre Melter and 1500 Litre Melter- The gelatin melter is used for the
processing of gelatin granules into a finished capsule base form.
During the gelatin batch both USP grade water, glycerin, and
sorbitol are automatically dispensed to the melter and mixed.
Gelatin granules are then added to the melter. A vacuum is now
pulled during the (CRACKING) process. The gelatin is check for
viscosity and dispensed into holding receivers.
Ystral Jetstream Mixer- The mixer is used for the addition
of colorant to the gelatin. This is an airless mixer which is
critical not to induce air in the finished capsule base.
Encapsulation
We have four 7.25" encapsulation machines with 8 basket dryers and two 12" encapsulation machines with a 20 basket and 24 basket dryer.
A 12" machine is capable of outputting over 175,000 capsules per hour. (7.5 oval) and the 7.25" machines are capable of outputting 67,500 capsules per hour (7.5 oval).
Video Microscope- This microscope allows for quality checks
of the seal of the capsule which is critical in the encapsulation
process. The operators and QA check four points on the
capsule lead, trail, and sides of the shell.
Analytical Balance- The balance is used for in process
weight check of the the capsule during the encapsulation process.
Inspection
Sortomat 12D- Automatic dimensional sorting of capsules
after visual inspection.
Hardness Tester- This unit test the hardness of the
capsules in Newton’s which co-relates to the finished moisture.
Packaging
IMA Blister Packager and Cartoner - This machine is capable of automatically forming blister packages and cartoning them while inserting a coupon or flyer at speeds up to 60 blisters a minute. A variety of tooling is being designed to accommodate a variety of capsule size and shapes as well as tablets, hardcapsules, and other solid dosage forms.
Air
Treatment
Kathabar- This unit is used for dehumidification in the
drying tunnels. The principle behind this is that the air which is
returned back from the drying tunnels has picked up moisture and
within the conditioner the air passes through a spray of lithium
chloride. The lithium chloride picks up the moisture and then is
passed through the regenerator and heated to release the moisture
to atmosphere. During this process the air the air is also cleaned
from bacteria. The Kathabar also has a Hepa filter installed on
the supply side.
Air Handling Unit- Gelcell is equipped with separate air
handling units in each individual area. Gelatin Preparation, Fill
preparation, Encapsulation, Inspection, Raw Material Sampling,
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